Role of Glutathione

     Glutathione is a tripeptide which is processed intracellularly from its constituent amino acids: L glutamate, L-cysteine ​​and glycine. The group of the sulfhydryl (SH) (thiol) of cysteine ​​is responsible for the biological activity of glutathione. The limiting factor in glutathione synthesis is the supply of this amino acid in cells whose presence in food is very difficult to achieve. The disulphide bond in the cysteine ​​is resistant to pepsin and trypsin but can be broken by heat, with low pH or by mechanical stress releasing unlinked cysteine. When subjected to heat or violent mechanical processes (inherent to most extraction processes), the fragile bonds between peptides bisulfates break and the bioavailability of cysteine ​​decreases considerably. Glutathione is a highly regulated intracellular constituent and its production is limited by the negative feedback inhibition of its own synthesis by the enzyme synthetase glutamylcystine range, thereby minimizing any possibility of overdose. Write to saludymax@gmail.com

     Glutathione plays multiple roles:1. Is the main endogenous antioxidant produced by the cells participating directly in the neutralization of free radicals and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as vitamins C and E in their reduced forms (active).2. Through direct conjugation, it detoxifies various xenobiotics (foreign compounds) and carcinogens, both organic and inorganic. Write to saludymax@gmail.com.

      It is essential for the immune system works to its full potential, ie, (1) modulating antigen presentation to lymphocytes and therefore influences the production of cytokines and the type of response (cellular or humoral) that develops , (2) enhances lymphocyte proliferation and thus increases the magnitude of response, (3) enhances the killing activity of cytotoxic T cells and NK (4) regulating apoptosis, thereby maintaining control of the immune response. Write to saludymax@gmail.com.
    
     Plays a fundamental role in numerous metabolic and biochemical reactions such as synthesis and DNA repair synthesis of proteins, amino acid transport and activation of the enzymes. Therefore, each system of our body can be affected by the state of glutathione system, especially the immune system, nervous system, gastrointestinal system and lungs.